Details
A Metaheuristic Approach to Protein Structure Prediction
Algorithms and Insights from Fitness Landscape AnalysisEmergence, Complexity and Computation, Band 31
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96,29 € |
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| Verlag: | Springer |
| Format: | |
| Veröffentl.: | 05.03.2018 |
| ISBN/EAN: | 9783319747750 |
| Sprache: | englisch |
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Beschreibungen
This book introduces characteristic features of the protein structure prediction (PSP) problem. It focuses on systematic selection and improvement of the most appropriate metaheuristic algorithm to solve the problem based on a fitness landscape analysis, rather than on the nature of the problem, which was the focus of methodologies in the past.<p> Protein structure prediction is concerned with the question of how to determine the three-dimensional structure of a protein from its primary sequence. Recently a number of successful metaheuristic algorithms have been developed to determine the native structure, which plays an important role in medicine, drug design, and disease prediction.</p><p> This interdisciplinary book consolidates the concepts most relevant to protein structure prediction (PSP) through global non-convex optimization. It is intended for graduate students from fields such as computer science, engineering, bioinformatics and as a reference for researchers and practitioners.</p>
Metaheuristic Protein Structure Prediction-An Overview.- Related Works.- Continuous Landscape Analysis using Random Walk Algorithm.- Landscape Characterization and Algorithms Selection for the PSP Problem.- The Levy distributed Parameter Adaptive Metaheuristic Algorithm for Protein Structure Prediction.- Protein Structure Prediction using Improved Variants of Metaheuristic Algorithms.- Hybrid Metaheuristic Approach for Protein Structure Prediction.- Conclusions and Future Research.<p></p>
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This book introduces characteristic features of the protein structure prediction (PSP) problem. It focuses on systematic selection and improvement of the most appropriate metaheuristic algorithm to solve the problem based on a fitness landscape analysis, rather than on the nature of the problem, which was the focus of methodologies in the past.<p> Protein structure prediction is concerned with the question of how to determine the three-dimensional structure of a protein from its primary sequence. Recently a number of successful metaheuristic algorithms have been developed to determine the native structure, which plays an important role in medicine, drug design, and disease prediction.</p><p> This interdisciplinary book consolidates the concepts most relevant to protein structure prediction (PSP) through global non-convex optimization. It is intended for graduate students from fields such as computer science, engineering, bioinformatics and as a reference for researchers and practitioners.</p>
Presents structural features of the protein-structure prediction (PSP) problem and well-known metaheuristic techniques Introduces algorithms and insights from fitness landscape analysis Demonstrates how to generate the protein landscape structure based on the sampling technique for determining the structural properties of the protein landscape
Presents structural features of the Protein-Structure Prediction (PSP) problem and well known metaheuristic techniques<p></p> <p>Introduces to Algorithms and Insights from Fitness Landscape Analysis</p><p>Demonstrates how to generate the protein landscape structure based on sampling technique for determining the structural properties of the protein landscape</p><p></p>
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